Ontology highlight
ABSTRACT:
SUBMITTER: Polonelli L
PROVIDER: S-EPMC5057116 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Scientific reports 20161011
A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the in ...[more]