Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability.
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ABSTRACT:
SUBMITTER: de Wilde MC
PROVIDER: S-EPMC5058345 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Publications
Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability.
de Wilde Martijn C MC Overk Cassia R CR Sijben John W JW Masliah Eliezer E
Alzheimer's & dementia : the journal of the Alzheimer's Association 20160114 6
<h4>Introduction</h4>Loss of synapses best correlates to cognitive deficits in Alzheimer's disease (AD) in which oligomeric neurotoxic species of amyloid-β appears to contribute synaptic pathology. Although a number of clinical pathologic studies have been performed with limited sample size, there are no systematic studies encompassing large samples. Therefore, we performed a meta-analysis study.<h4>Methods</h4>We identified 417 publications reporting postmortem synapse and synaptic marker loss ...[more]
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