Ontology highlight
ABSTRACT:
SUBMITTER: Volz-Lingenhohl A
PROVIDER: S-EPMC50585 | biostudies-other | 1992 Dec
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19921201 23
Due to the extremely economic organization of the animal mitochondrial genome, large-scale deletions are rarely found in animal mtDNA. We report the occurrence of a massive deletion in the coding region of mtDNA in Drosophila subobscura. Restriction mapping and nucleotide sequence analysis revealed that the deletion encompasses six protein genes and four tRNAs. All individuals of an isofemale strain proved to be heteroplasmic for normal and deficient mtDNA molecules. This type of heteroplasmy re ...[more]