Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5.
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ABSTRACT:
SUBMITTER: Contractor T
PROVIDER: S-EPMC5058703 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
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Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5.
Contractor Tanupriya T Kobayashi Shinta S da Silva Edaise E Clausen Richard R Chan Chang C Vosburgh Evan E Tang Laura H LH Levine Arnold J AJ Harris Chris R CR
Oncotarget 20160501 21
In a mouse model for neuroendocrine tumors of the pancreas (PanNETs), liver metastasis occurred at a higher frequency in males. Male mice also had higher serum and intratumoral levels of the innate immunity protein complement C5. In mice that lost the ability to express complement C5, there was a lower frequency of metastasis, and males no longer had a higher frequency of metastasis than females. Treatment with PMX53, a small molecule antagonist of C5aR1/CD88, the receptor for complement C5a, al ...[more]
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