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Quantitative single-photon emission computed tomography/computed tomography for technetium pertechnetate thyroid uptake measurement.


ABSTRACT: Technetium pertechnetate (TcO4) is a radioactive tracer used to assess thyroid function by thyroid uptake system (TUS). However, the TUS often fails to deliver accurate measurements of the percent of thyroid uptake (%thyroid uptake) of TcO4. Here, we investigated the usefulness of quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) after injection of TcO4 in detecting thyroid function abnormalities.We retrospectively reviewed data from 50 patients (male:female = 15:35; age, 46.2?±?16.3 years; 17 Graves disease, 13 thyroiditis, and 20 euthyroid). All patients underwent TcO4 quantitative SPECT/CT (185 MBq = 5 mCi), which yielded %thyroid uptake and standardized uptake value (SUV). Twenty-one (10 Graves disease and 11 thyroiditis) of the 50 patients also underwent conventional %thyroid uptake measurements using a TUS.Quantitative SPECT/CT parameters (%thyroid uptake, SUVmean, and SUVmax) were the highest in Graves disease, second highest in euthyroid, and lowest in thyroiditis (P?

SUBMITTER: Lee H 

PROVIDER: S-EPMC5058868 | biostudies-other | 2016 Jul

REPOSITORIES: biostudies-other

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Quantitative single-photon emission computed tomography/computed tomography for technetium pertechnetate thyroid uptake measurement.

Lee Hyunjong H   Kim Ji Hyun JH   Kang Yeon-Koo YK   Moon Jae Hoon JH   So Young Y   Lee Won Woo WW  

Medicine 20160701 27


<h4>Objectives</h4>Technetium pertechnetate (TcO4) is a radioactive tracer used to assess thyroid function by thyroid uptake system (TUS). However, the TUS often fails to deliver accurate measurements of the percent of thyroid uptake (%thyroid uptake) of TcO4. Here, we investigated the usefulness of quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) after injection of TcO4 in detecting thyroid function abnormalities.<h4>Materials and methods</h4>We retrospecti  ...[more]

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