Ontology highlight
ABSTRACT:
SUBMITTER: Stadler HS
PROVIDER: S-EPMC50596 | biostudies-other | 1992 Dec
REPOSITORIES: biostudies-other
Stadler H S HS Padanilam B J BJ Buetow K K Murray J C JC Solursh M M
Proceedings of the National Academy of Sciences of the United States of America 19921201 23
A human craniofacial cDNA library was screened with a degenerate oligonucleotide probe based on the conserved third helix of homeobox genes. From this screening, we identified a homeobox gene, H6, which shared only 57-65% amino acid identity to previously reported homeodomains. H6 was physically mapped to the 4p16.1 region by using somatic cell hybrids containing specific deletions of human chromosome 4. Linkage data from a single-stranded conformational polymorphism derived from the 3' untransl ...[more]