Ontology highlight
ABSTRACT:
SUBMITTER: Nautiyal KM
PROVIDER: S-EPMC5061886 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Nautiyal Katherine M KM Tritschler Laurent L Ahmari Susanne E SE David Denis J DJ Gardier Alain M AM Hen René R
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20160629 12
The effects of serotonin (5-HT) on anxiety and depression are mediated by a number of 5-HT receptors, including autoreceptors that act to inhibit 5-HT release. While the majority of anxiety and depression-related research has focused on the 5-HT<sub>1A</sub> receptor, the 5-HT<sub>1B</sub> receptor has a lesser known role in modulating emotional behavior. 5-HT<sub>1B</sub> receptors are inhibitory GPCRs located on the presynaptic terminal of both serotonin and non-serotonin neurons, where they a ...[more]