Dataset Information
Combined Interactions with I1-, I2-Imidazoline Binding Sites and ?2-Adrenoceptors To Manage Opioid Addiction.
Ontology highlight
ABSTRACT:
SUBMITTER: Giusepponi ME
PROVIDER: S-EPMC5066154 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Publications
Combined Interactions with I<sub>1</sub>-, I<sub>2</sub>-Imidazoline Binding Sites and α<sub>2</sub>-Adrenoceptors To Manage Opioid Addiction.
ACS medicinal chemistry letters 20160908 10
Tolerance and dependence associated with chronic opioid exposure result from molecular, cellular, and neural network adaptations. Such adaptations concern opioid and nonopioid systems, including α<sub>2</sub>-adrenoceptors (α<sub>2</sub>-ARs) and I<sub>1</sub>- and I<sub>2</sub>-imidazoline binding sites (IBS). Agmatine, one of the hypothesized endogenous ligands of IBS, targeting several systems including α<sub>2</sub>-ARs and IBS, proved to be able to regulate opioid-induced analgesia and to a ...[more]
