Ontology highlight
ABSTRACT:
SUBMITTER: DuBois JM
PROVIDER: S-EPMC5066831 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
DuBois Jonathan M JM Rousset Olivier G OG Guiot Marie-Christine MC Hall Jeffery A JA Reader Andrew J AJ Soucy Jean-Paul JP Rosa-Neto Pedro P Kobayashi Eliane E
Cerebral cortex (New York, N.Y. : 1991) 20161001 11
Metabotropic glutamate receptor type 5 (mGluR5) abnormalities have been described in tissue resected from epilepsy patients with focal cortical dysplasia (FCD). To determine if these abnormalities could be identified in vivo, we investigated mGluR5 availability in 10 patients with focal epilepsy and an MRI diagnosis of FCD using positron-emission tomography (PET) and the radioligand [11C]ABP688. Partial volume corrected [11C]ABP688 binding potentials (BPND) were computed using the cerebellum as ...[more]