Ontology highlight
ABSTRACT:
SUBMITTER: Leifer CA
PROVIDER: S-EPMC5069093 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Journal of leukocyte biology 20160624 5
TLRs play a critical role in the detection of microbes and endogenous "alarmins" to initiate host defense, yet they can also contribute to the development and progression of inflammatory and autoimmune diseases. To avoid pathogenic inflammation, TLR signaling is subject to multilayer regulatory control mechanisms, including cooperation with coreceptors, post-translational modifications, cleavage, cellular trafficking, and interactions with negative regulators. Nucleic acid-sensing TLRs are parti ...[more]