Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC5069493 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Chen Gang G Yu Dongsheng D Nian Xue X Liu Junyi J Koenig Ronald J RJ Xu Bin B Sheng Liang L
Scientific reports 20161019
Nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease, manifests as an over-accumulation of hepatic fat. We have recently shown that mice with genetic knockout of a long non-coding RNA (lncRNA) steroid receptor RNA activator (SRA) (SRAKO) are resistant to high fat diet-induced obesity with a phenotype that includes improved glucose tolerance and attenuated hepatic steatosis. The underlying mechanism was investigated in the present study. We found that hepatic le ...[more]