Ontology highlight
ABSTRACT:
SUBMITTER: Mangala LS
PROVIDER: S-EPMC5070952 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Mangala Lingegowda S LS Wang Hongyu H Jiang Dahai D Wu Sherry Y SY Somasunderam Anoma A Volk David E DE Lokesh Ganesh L R GLR Li Xin X Pradeep Sunila S Yang Xianbin X Haemmerle Monika M Rodriguez-Aguayo Cristian C Nagaraja Archana S AS Rupaimoole Rajesha R Bayraktar Emine E Bayraktar Recep R Li Li L Tanaka Takemi T Hu Wei W Ivan Cristina C Gharpure Kshipra M KM McGuire Michael H MH Thiviyanathan Varatharasa V Zhang Xinna X Maiti Sourindra N SN Bulayeva Nataliya N Choi Hyun-Jin HJ Dorniak Piotr L PL Cooper Laurence Jn LJ Rosenblatt Kevin P KP Lopez-Berestein Gabriel G Gorenstein David G DG Sood Anil K AK
JCI insight 20161020 17
Current antiangiogenesis therapy relies on inhibiting newly developed immature tumor blood vessels and starving tumor cells. This strategy has shown transient and modest efficacy. Here, we report a better approach to target cancer-associated endothelial cells (ECs), reverse permeability and leakiness of tumor blood vessels, and improve delivery of chemotherapeutic agents to the tumor. First, we identified deregulated microRNAs (miRs) from patient-derived cancer-associated ECs. Silencing these mi ...[more]