Ontology highlight
ABSTRACT:
SUBMITTER: Romorini L
PROVIDER: S-EPMC5071844 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Romorini Leonardo L Garate Ximena X Neiman Gabriel G Luzzani Carlos C Furmento Verónica Alejandra VA Guberman Alejandra Sonia AS Sevlever Gustavo Emilio GE Scassa María Elida ME Miriuka Santiago Gabriel SG
Scientific reports 20161020
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (PSC) that can differentiate into a wide range of specialized cells. Basic fibroblast growth factor is essential for PSC survival, stemness and self-renewal. PI3K/AKT pathway regulates cell viability and apoptosis in many cell types. Although it has been demonstrated that PI3K/AKT activation by bFGF is relevant for PSC stemness maintenance its role on PSC survival remains elusive. In this study we explore ...[more]