Ontology highlight
ABSTRACT:
SUBMITTER: Allen M
PROVIDER: S-EPMC5071868 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Allen Megan M Ghosh Suhasini S Ahern Gerard P GP Villapol Sonia S Maguire-Zeiss Kathleen A KA Conant Katherine K
Scientific reports 20161020
Matrix metalloproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia. Regulated MMP activity contributes to physiological synaptic plasticity, while dysregulated activity can stimulate injury. Disentangling the role individual MMPs play in synaptic plasticity is difficult due to overlapping structure and function as well as cell-type specific expression. Here, we develop a novel system to investigate the selective overexpression of a single MMP driven by GFAP ex ...[more]