Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5071891 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Yang Jian J Yang Jing J Liang Steven H SH Xu Yungen Y Moore Anna A Ran Chongzhao C
Scientific reports 20161020
In brains of Alzheimer's disease (AD), reactive oxygen species (ROS) levels are significantly higher than that of healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around amyloid beta (Aβ) production, aggregation, plaque formation, microglia/immunological responses, inflammation, and ROS production. In this cycle, ROS species play a central role, and H<sub>2</sub>O<sub>2</sub> is one of the most important ROS species. In this report, we have design ...[more]