Ontology highlight
ABSTRACT:
SUBMITTER: Menoud PA
PROVIDER: S-EPMC507332 | biostudies-other | 1996 Jun
REPOSITORIES: biostudies-other
Menoud P A PA Sappino N N Boudal-Khoshbeen M M Vassalli J D JD Sappino A P AP
The Journal of clinical investigation 19960601 11
The serpin alpha2-antiplasmin (alpha2-AP) is the major circulating inhibitor of plasmin; it plays a determining role in the regulation of intravascular fibrinolysis, In addition to blood plasma, plasmin formation occurs in various organs where it is thought to fulfill a spectrum of functions not restricted to clot lysis. Alpha2-AP is synthesized by hepatocytes, but other possible sites of production have not been investigated. To explore the potential extravascular contribution of alpha2-AP in t ...[more]