Ontology highlight
ABSTRACT:
SUBMITTER: Vidal-Bralo L
PROVIDER: S-EPMC5076459 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Vidal-Bralo Laura L Lopez-Golan Yolanda Y Mera-Varela Antonio A Rego-Perez Ignacio I Horvath Steve S Zhang Yuhua Y Del Real Álvaro Á Zhai Guangju G Blanco Francisco J FJ Riancho Jose A JA Gomez-Reino Juan J JJ Gonzalez Antonio A
Aging 20160901 9
Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age-measures (DmAM) were used: the multi-tissue age estimator for cartilage and bone ...[more]