Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC5076566 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Lin Yi Y Mori Eiichiro E Kato Masato M Xiang Siheng S Wu Leeju L Kwon Ilmin I McKnight Steven L SL
Cell 20161001 3
Two complementary approaches were used in search of the intracellular targets of the toxic PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of amyotrophic lateral sclerosis. The top categories of PR<sub>n</sub>-bound proteins include constituents of non-membrane invested cellular organelles and intermediate filaments. PR<sub>n</sub> targets are enriched for the inclusion of low complexity (LC) sequences. Evidence is presented indicating that LC sequences represent t ...[more]