Ontology highlight
ABSTRACT:
SUBMITTER: Yao K
PROVIDER: S-EPMC5076887 | biostudies-other | 2016 Sep
REPOSITORIES: biostudies-other
Yao Kai K Qiu Suo S Tian Lin L Snider William D WD Flannery John G JG Schaffer David V DV Chen Bo B
Cell reports 20160901 1
In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as they do not spontaneously re-enter the cell cycle unless the retina is injured. Here, we show that gene transfer of β-catenin in adult mouse retinas activates Wnt signaling and MG proliferation without retinal injury. Upstream of Wnt, deletion of GSK3β stabilizes β-catenin and activates MG proliferation. Downstream ...[more]