Ontology highlight
ABSTRACT:
SUBMITTER: Roben P
PROVIDER: S-EPMC507750 | biostudies-other | 1996 Dec
REPOSITORIES: biostudies-other
Roben P P Barbas S M SM Sandoval L L Lecerf J M JM Stollar B D BD Solomon A A Silverman G J GJ
The Journal of clinical investigation 19961201 12
To investigate the autoantibody repertoire associated with SLE, we have created phage display IgG Fab libraries from two clinically active SLE patients and from the healthy identical twin of one of these patients. The libraries from the lupus discordant twins were found to both include unusually large representations of the V(H)5 gene family. By panning with DNA, the SLE libraries each yielded IgG anti-double-stranded (ds) DNA autoantibodies, which are characteristic of lupus disease. These incl ...[more]