Ontology highlight
ABSTRACT:
SUBMITTER: Beedie SL
PROVIDER: S-EPMC5078090 | biostudies-other | 2016 May
REPOSITORIES: biostudies-other
Oncotarget 20160501 22
Thalidomide, a drug known for its teratogenic side-effects, is used successfully to treat a variety of clinical conditions including leprosy and multiple myeloma. Intense efforts are underway to synthesize and identify safer, clinically relevant analogs. Here, we conduct a preliminary in vivo screen of a library of new thalidomide analogs to determine which agents demonstrate activity, and describe a cohort of compounds with anti-angiogenic properties, anti-inflammatory properties and some compo ...[more]