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Modular decomposition of protein-protein interaction networks.

ABSTRACT: We introduce an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. Modular decomposition derives the logical rules of how to combine proteins into the actual functional complexes by identifying groups of proteins acting as a single unit (sub-complexes) and those that can be alternatively exchanged in a set of similar complexes. The method is applied to experimental data on the pro-inflammatory tumor necrosis factor-alpha (TNF-alpha)/NFkappaB transcription factor pathway.

SUBMITTER: Gagneur J 

PROVIDER: S-EPMC507882 | biostudies-other | 2004

REPOSITORIES: biostudies-other

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Modular decomposition of protein-protein interaction networks.

Gagneur Julien J   Krause Roland R   Bouwmeester Tewis T   Casari Georg G  

Genome biology 20040721 8

We introduce an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. Modular decomposition derives the logical rules of how to combine proteins into the actual functional complexes by identifying groups of proteins acting as a single unit (sub-complexes) and those that can be alternatively exchanged in a set of similar complexes. The method is applied to experimental data on the pro-inflammatory tumor ne  ...[more]