Ontology highlight
ABSTRACT:
SUBMITTER: Gantz I
PROVIDER: S-EPMC50824 | biostudies-other | 1991 Jan
REPOSITORIES: biostudies-other
Gantz I I Schäffer M M DelValle J J Logsdon C C Campbell V V Uhler M M Yamada T T
Proceedings of the National Academy of Sciences of the United States of America 19910101 2
The H2 subclass of histamine receptors mediates gastric acid secretion, and antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. The physiological action of histamine has been shown to be mediated via a guanine nucleotide-binding protein linked to adenylate cyclase activation and cellular cAMP generation. We capitalized on the technique of polymerase chain reaction, using degenerate oligonucleotide primers based on the known h ...[more]