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Oligometastatic Prostate Cancer.

ABSTRACT: The mainstay of treatment for men with three or fewer non-castrate metastatic lesions outside of the prostate remains morbid palliative androgen deprivation therapy. We believe there is now a significant body of retrospective literature to suggest a survival benefit if these men have radical treatment to their primary tumour alongside 'metastasis-directed therapy' to the metastatic deposits. However, this regimen should be reserved to high-volume centres with quality assurance programmes and excellent outcomes. Patients should be made clear as to the uncertainty of benefit for this multi-site treatment strategy, and we await the publication of randomised controlled trials reporting in the next 5 years.

SUBMITTER: Stevens DJ

PROVIDER: S-EPMC5083765 | biostudies-other | 2016 Dec

REPOSITORIES: biostudies-other

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Oligometastatic Prostate Cancer.

Stevens Daniel J DJ Sooriakumaran Prasanna P

Current treatment options in oncology 20161201 12

<h4>Opinion statement</h4>The mainstay of treatment for men with three or fewer non-castrate metastatic lesions outside of the prostate remains morbid palliative androgen deprivation therapy. We believe there is now a significant body of retrospective literature to suggest a survival benefit if these men have radical treatment to their primary tumour alongside 'metastasis-directed therapy' to the metastatic deposits. However, this regimen should be reserved to high-volume centres with quality as ...[more]

PMID: 27787754

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