Ontology highlight
ABSTRACT:
SUBMITTER: Baldwin ET
PROVIDER: S-EPMC50839 | biostudies-other | 1991 Jan
REPOSITORIES: biostudies-other
Baldwin E T ET Weber I T IT St Charles R R Xuan J C JC Appella E E Yamada M M Matsushima K K Edwards B F BF Clore G M GM Gronenborn A M AM
Proceedings of the National Academy of Sciences of the United States of America 19910101 2
The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the ...[more]