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Crystal structure of interleukin 8: symbiosis of NMR and crystallography.


ABSTRACT: The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.

SUBMITTER: Baldwin ET 

PROVIDER: S-EPMC50839 | biostudies-other | 1991 Jan

REPOSITORIES: biostudies-other

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Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

Baldwin E T ET   Weber I T IT   St Charles R R   Xuan J C JC   Appella E E   Yamada M M   Matsushima K K   Edwards B F BF   Clore G M GM   Gronenborn A M AM  

Proceedings of the National Academy of Sciences of the United States of America 19910101 2


The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the  ...[more]

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