Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.
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ABSTRACT:
SUBMITTER: Flajnik MF
PROVIDER: S-EPMC50846 | biostudies-other | 1991 Jan
REPOSITORIES: biostudies-other
Publications
Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.
Flajnik M F MF Canel C C Kramer J J Kasahara M M
Proceedings of the National Academy of Sciences of the United States of America 19910101 2
Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of rep ...[more]
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