Ontology highlight
ABSTRACT:
SUBMITTER: Oliva C
PROVIDER: S-EPMC5084709 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Oliva Carlos C Soldano Alessia A Mora Natalia N De Geest Natalie N Claeys Annelies A Erfurth Maria-Luise ML Sierralta Jimena J Ramaekers Ariane A Dascenco Dan D Ejsmont Radoslaw K RK Schmucker Dietmar D Sanchez-Soriano Natalia N Hassan Bassem A BA
Developmental cell 20161001 2
The axonal wiring molecule Slit and its Round-About (Robo) receptors are conserved regulators of nerve cord patterning. Robo receptors also contribute to wiring brain circuits. Whether molecular mechanisms regulating these signals are modified to fit more complex brain wiring processes is unclear. We investigated the role of Slit and Robo receptors in wiring Drosophila higher-order brain circuits and identified differences in the cellular and molecular mechanisms of Robo/Slit function. First, we ...[more]