Dataset Information
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides.
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ABSTRACT:
SUBMITTER: Salomo E
PROVIDER: S-EPMC5084810 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Publications
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides.
Angewandte Chemie (International ed. in English) 20160517 28
The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly so ...[more]