Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Garcia C
PROVIDER: S-EPMC5087596 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
García-García Celina C Rivas Martín A MA Ibrahim Yasir H YH Calvo María Teresa MT Gris-Oliver Albert A Rodríguez Olga O Grueso Judit J Antón Pilar P Guzmán Marta M Aura Claudia C Nuciforo Paolo P Jessen Katti K Argilés Guillem G Dienstmann Rodrigo R Bertotti Andrea A Trusolino Livio L Matito Judit J Vivancos Ana A Chicote Irene I Palmer Héctor G HG Tabernero Josep J Scaltriti Maurizio M Baselga José J Serra Violeta V
Clinical cancer research : an official journal of the American Association for Cancer Research 20150813 24
<h4>Purpose</h4>PI3K pathway activation occurs in concomitance with RAS/BRAF mutations in colorectal cancer, limiting the sensitivity to targeted therapies. Several clinical studies are being conducted to test the tolerability and clinical activity of dual MEK and PI3K pathway blockade in solid tumors.<h4>Experimental design</h4>In the present study, we explored the efficacy of dual pathway blockade in colorectal cancer preclinical models harboring concomitant activation of the ERK and PI3K path ...[more]