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Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis.

ABSTRACT: Contact of axons with target territories results in the formation of synapses, specific junctional complexes that may represent a final stage of neuronal maturation. Synaptosomal-associated protein 25 (SNAP-25) is a component of particular nerve terminals recently identified in rodent brain. To evaluate the structure and regulation of molecular components of the synapse, we investigated the expression of SNAP-25 in the developing chicken nervous system. Analysis of SNAP-25 cDNA clones demonstrated that the chicken homologue is identical in amino acid sequence to the mouse protein. In chicken retina and neural tube, the onset of SNAP-25 mRNA and protein expression was found to correspond to the time of synaptogenesis. These results suggest that SNAP-25 plays a role in the physiology of mature nerve terminals and that its expression may be regulated by specific cell-cell interactions occurring during synapse formation.

SUBMITTER: Catsicas S

PROVIDER: S-EPMC50898 | biostudies-other | 1991 Feb

REPOSITORIES: biostudies-other

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Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis.

Catsicas S S Larhammar D D Blomqvist A A Sanna P P PP Milner R J RJ Wilson M C MC

Proceedings of the National Academy of Sciences of the United States of America 19910201 3

Contact of axons with target territories results in the formation of synapses, specific junctional complexes that may represent a final stage of neuronal maturation. Synaptosomal-associated protein 25 (SNAP-25) is a component of particular nerve terminals recently identified in rodent brain. To evaluate the structure and regulation of molecular components of the synapse, we investigated the expression of SNAP-25 in the developing chicken nervous system. Analysis of SNAP-25 cDNA clones demonstrat ...[more]

PMID: 1992470

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Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis.

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Expression of a conserved cell-type-specific protein in nerve terminals coincides with synaptogenesis.

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