Ontology highlight
ABSTRACT:
SUBMITTER: Begley CG
PROVIDER: S-EPMC50915 | biostudies-other | 1991 Feb
REPOSITORIES: biostudies-other
Begley C G CG Visvader J J Green A R AR Aplan P D PD Metcalf D D Kirsch I R IR Gough N M NM
Proceedings of the National Academy of Sciences of the United States of America 19910201 3
The human SCL gene is a member of the family of genes that encode the helix-loop-helix (HLH) class of DNA-binding proteins. A murine SCL cDNA was isolated from a normal macrophage cDNA library by using HLH-specific oligonucleotides as hybridization probes. The coding region is 987 base pairs and encodes a predicted protein of 34 kDa. The nucleotide sequence of the coding region shows 88% identity to the human SCL gene, and the amino acid sequence is 94% identical. The HLH motif and upstream hydr ...[more]