Ontology highlight
ABSTRACT:
SUBMITTER: Bhola PD
PROVIDER: S-EPMC5096802 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Bhola Patrick D PD Mar Brenton G BG Lindsley R Coleman RC Ryan Jeremy A JA Hogdal Leah J LJ Vo Thanh Trang TT DeAngelo Daniel J DJ Galinsky Ilene I Ebert Benjamin L BL Letai Anthony A
The Journal of clinical investigation 20160906 10
Upfront resistance to chemotherapy and relapse following remission are critical problems in leukemia that are generally attributed to subpopulations of chemoresistant tumor cells. There are, however, limited means for prospectively identifying these subpopulations, which hinders an understanding of therapeutic resistance. BH3 profiling is a functional single-cell analysis using synthetic BCL-2 BH3 domain-like peptides that measures mitochondrial apoptotic sensitivity or "priming." Here, we obser ...[more]