LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation.
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ABSTRACT:
SUBMITTER: Park MY
PROVIDER: S-EPMC5099895 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Publications
LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation.
Park Mi Young MY Sudan Raki R Srivastava Neetu N Neelam Sudha S Youngs Christie C Wang Jia-Wang JW Engelman Robert W RW Kerr William G WG
Scientific reports 20161108
The PH-BEACH-WD40 (PBW) protein family members play a role in coordinating receptor signaling and intracellular vesicle trafficking. LPS-Responsive-Beige-like Anchor (LRBA) is a PBW protein whose immune function remains elusive. Here we show that LRBA-null mice are viable, but exhibit compromised rejection of allogeneic, xenogeneic and missing self bone-marrow grafts. Further, we demonstrate that LRBA-null Natural Killer (NK) cells exhibit impaired signaling by the key NK activating receptors, N ...[more]
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