Ontology highlight
ABSTRACT:
SUBMITTER: Smythe JA
PROVIDER: S-EPMC51102 | biostudies-other | 1991 Mar
REPOSITORIES: biostudies-other
Smythe J A JA Coppel R L RL Day K P KP Martin R K RK Oduola A M AM Kemp D J DJ Anders R F RF
Proceedings of the National Academy of Sciences of the United States of America 19910301 5
Antigens associated with the surface of merozoites of the malaria parasite Plasmodium falciparum are directly accessible to immune attack and therefore are prime vaccine candidates. We have previously shown that one of the two known merozoite surface antigens (merozoite surface antigen 2; MSA-2) exhibits considerable sequence and antigenic diversity in different isolates. The sequences of MSA-2 from three isolates revealed a central domain composed of repeats that vary in number, length, and seq ...[more]