Ontology highlight
ABSTRACT:
SUBMITTER: Yuan L
PROVIDER: S-EPMC5111840 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Yuan Lunzhi L Wang Tengyun T Zhang Yali Y Liu Xuan X Zhang Tianying T Li Xiaoling X Liu Pingguo P Wu Kun K Shih James Wai Kuo JW Yuan Quan Q Cheng Tong T Xia Ningshao N
Experimental animals 20160606 4
Hepatitis B virus (HBV) is the leading cause of liver disease and hepatic carcinoma (HCC). Approximately 350 million people worldwide are infected with HBV and at risk of chronicity. An efficient HBV-tolerant murine model that mimics HBV infection in humans is desirable for HBV-related research. In this study, we investigated and established a murine model by hydrodynamic injection (HDI) of pAAV/HBV into the tail vein of AAVS1 site element-transgenic mice. In 80% of the injected mice, the serum ...[more]