Ontology highlight
ABSTRACT:
SUBMITTER: Tannich E
PROVIDER: S-EPMC51123 | biostudies-other | 1991 Mar
REPOSITORIES: biostudies-other
Tannich E E Ebert F F Horstmann R D RD
Proceedings of the National Academy of Sciences of the United States of America 19910301 5
The adherence of Entamoeba histolytica to colonic mucins and to host cells appears to be predominantly mediated by a 170-kDa surface lectin of the amoebae. By using an antiserum to the purified lectin, the corresponding cDNA was isolated from an expression library of the pathogenic E. histolytica isolate HM-1:IMSS. Northern blot analysis indicated a transcript of approximately 4 kilobases, and Southern blot analyses suggested that multiple genes may encode the lectin or closely related proteins ...[more]