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Trends in steroid therapy for Duchenne muscular dystrophy in Japan.


ABSTRACT: We conducted a study to reveal trends in steroid prescription for Duchenne muscular dystrophy (DMD) patients in Japan.We asked patients (ages 5-20 years) identified in the patient registry and their clinicians about steroid therapy experiences. Regimen, dose, and starting age were compared among 3 subgroups according to prednisolone initiation year (2000-2004, 2005-2009, and 2010-2013).Among 157 prednisolone users, 4 different regimens were used. Dose frequencies were: every other day (98 patients), daily (44 patients), 10 days on 20 days off (14 patients), and weekly (1 patient). Median starting age was 6 years, and median dose was 0.42 mg/kg/day. There was an increase in daily regimen use from 2005-2009 (n = 9, 16%) to 2010-2013 (n = 33, 36%).This study revealed a transition over time in steroid use from expert opinion to evidence-based recommendation. Clinical research should be encouraged to optimize medication worldwide. Muscle Nerve 54: 673-680, 2016.

SUBMITTER: Takeuchi F 

PROVIDER: S-EPMC5113709 | biostudies-other | 2016 Oct

REPOSITORIES: biostudies-other

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Trends in steroid therapy for Duchenne muscular dystrophy in Japan.

Takeuchi Fumi F   Komaki Hirofumi H   Nakamura Harumasa H   Yonemoto Naohiro N   Kashiwabara Kousuke K   Kimura En E   Takeda Shin'ichi S  

Muscle & nerve 20160714 4


<h4>Introduction</h4>We conducted a study to reveal trends in steroid prescription for Duchenne muscular dystrophy (DMD) patients in Japan.<h4>Methods</h4>We asked patients (ages 5-20 years) identified in the patient registry and their clinicians about steroid therapy experiences. Regimen, dose, and starting age were compared among 3 subgroups according to prednisolone initiation year (2000-2004, 2005-2009, and 2010-2013).<h4>Results</h4>Among 157 prednisolone users, 4 different regimens were us  ...[more]

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