Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC5115895 | biostudies-other | 2016 Oct
REPOSITORIES: biostudies-other
Kim Joohwee J Vaish Vivek V Feng Mingxiao M Field Kevin K Chatzistamou Ioulia I Shim Minsub M
Aging 20161001 10
Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids, lipid signaling molecules that regulate various physiological processes. COX2, one of the isoforms of COX, is highly inducible in response to a wide variety of cellular and environmental stresses. Increased COX2 expression is thought to play a role in the pathogenesis of many age-related diseases. COX2 expression is also reported to be increased in the tissues of aged humans and mice, which suggests the involvement of COX2 ...[more]