Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes.
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ABSTRACT:
SUBMITTER: de Gonzalo-Calvo D
PROVIDER: S-EPMC5118808 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Publications
Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes.
de Gonzalo-Calvo D D Kenneweg F F Bang C C Toro R R van der Meer R W RW Rijzewijk L J LJ Smit J W JW Lamb H J HJ Llorente-Cortes V V Thum T T
Scientific reports 20161122
Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in ...[more]
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