Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities.
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ABSTRACT:
SUBMITTER: Boucle S
PROVIDER: S-EPMC5119551 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
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Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities.
Boucle Sebastien S Bassit Leda L Ehteshami Maryam M Schinazi Raymond F RF
Clinics in liver disease 20160830 4
Hepatitis B virus (HBV) causes significant morbidity and mortality worldwide. The majority of chronically infected individuals do not achieve a functional and complete cure. Treated persons who achieve a long-term sustained virologic response (undetectable HBV DNA), are still at high risk of developing morbidity and mortality from liver complications. This review focuses on novel, mechanistically diverse anti-HBV therapeutic strategies currently in development or in clinical evaluation, and high ...[more]
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