Ontology highlight
ABSTRACT:
SUBMITTER: Tamura T
PROVIDER: S-EPMC5120204 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Nature communications 20161118
Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled receptor. Hypoparathyroidism and osteoporosis can be treated with PTH injections; however, no orally effective PTH analogue is available. Here we show that PCO371 is a novel, orally active small molecule that acts as a full agonist of PTHR1. PCO371 does not affect the PTH type 2 receptor (PTHR2), and analysis using PTHR1-PTHR2 chimeric receptor ...[more]