The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.
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ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC5123080 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Publications
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.
Zhang Feng F Prahst Claudia C Mathivet Thomas T Pibouin-Fragner Laurence L Zhang Jiasheng J Genet Gael G Tong Raymond R Dubrac Alexandre A Eichmann Anne A
Nature communications 20161124
Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4<sup>-/-</sup> mice that develop hyperpermeability, but how Robo4 signals remained unclear. Here we show that Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy (OIR) and accelerates cutaneous wound healing. To determine Robo4 ...[more]
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