Ontology highlight
ABSTRACT:
SUBMITTER: Gil D
PROVIDER: S-EPMC5126188 | biostudies-other | 2016 Nov
REPOSITORIES: biostudies-other
Gil Dorota D Ciołczyk-Wierzbicka Dorota D Dulińska-Litewka Joanna J Laidler Piotr P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20160928 11
Cadherin switch is specific of epithelial-mesenchymal transition (EMT) and is closely related to tumor cell invasion. However, the molecular mechanism that promotes the phenotypic changes remains unclear and elusive. We found that integrin-linked kinase (ILK) is a key factor involved in cadherin switch. The expression and activity of ILK are elevated in a variety of cancers but its mechanisms are not exactly understood. In this report, we studied the role and mechanism of ILK in EMT of human bla ...[more]