Ontology highlight
ABSTRACT:
SUBMITTER: Tagde A
PROVIDER: S-EPMC5129907 | biostudies-other | 2016 Jun
REPOSITORIES: biostudies-other
Tagde Ashujit A Rajabi Hasan H Stroopinsky Dina D Gali Reddy R Alam Maroof M Bouillez Audrey A Kharbanda Surender S Stone Richard R Avigan David D Kufe Donald D
Oncotarget 20160601 26
Aberrant DNA methylation is a hallmark of acute myeloid leukemia (AML); however, the regulation of DNA methyltransferase 1 (DNMT1), which is responsible for maintenance of DNA methylation patterns, has largely remained elusive. MUC1-C is a transmembrane oncoprotein that is aberrantly expressed in AML stem-like cells. The present studies demonstrate that targeting MUC1-C with silencing or a pharmacologic inhibitor GO-203 suppresses DNMT1 expression. In addition, MUC1 expression positively correla ...[more]