Ontology highlight
ABSTRACT:
SUBMITTER: Melikhova EY
PROVIDER: S-EPMC5132153 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20160715 33
The total synthesis of dehydromicrosclerodermin B and microsclerodermin J is described. Efficient approaches to the unusual amino acids in the target molecules were developed on the basis of a Negishi coupling (for Trp-2-CO2 H) and Blaise reaction (for Pyrr). An incorrect assignment of the pyrrolidinone stereochemistry of both compounds was confirmed by synthesizing epimers of the proposed structures. The spectroscopic data of these epimers were in complete agreement with those for the naturally ...[more]