Ontology highlight
ABSTRACT:
SUBMITTER: Han HD
PROVIDER: S-EPMC5133713 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Han Hee Dong HD Byeon Yeongseon Y Jang Jong-Hwa JH Jeon Hat Nim HN Kim Ga Hee GH Kim Min Gi MG Pack Chan-Gi CG Kang Tae Heung TH Jung In Duk ID Lim Yong Taik YT Lee Young Joo YJ Lee Jeong-Won JW Shin Byung Cheol BC Ahn Hyung Jun HJ Sood Anil K AK Park Yeong-Min YM
Scientific reports 20161202
Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections and elaborates ex vivo manipulation, which substantially limits their use. Therefore, we sought to develop a chitosan nanoparticle (CH-NP)-based platform for the next generation of vaccines to bypass the ex vivo manipulation and induce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) to target T ...[more]