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Conducting polymer-based multilayer films for instructive biomaterial coatings.

ABSTRACT: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment.Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ.Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current.We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues.

SUBMITTER: Hardy JG

PROVIDER: S-EPMC5137882 | biostudies-other | 2015 Nov

REPOSITORIES: biostudies-other

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Conducting polymer-based multilayer films for instructive biomaterial coatings.

Hardy John G JG Li Hetian H Chow Jacqueline K JK Geissler Sydney A SA McElroy Austin B AB Nguy Lindsey L Hernandez Derek S DS Schmidt Christine E CE

Future science OA 20151102 4

<h4>Aim</h4>To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment.<h4>Materials & methods</h4>Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through t ...[more]

PMID: 28031928

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Dataset Information

Conducting polymer-based multilayer films for instructive biomaterial coatings.

Publications

Conducting polymer-based multilayer films for instructive biomaterial coatings.

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