The role and therapeutic targeting of ?-, ?- and ?-secretase in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: MacLeod R
PROVIDER: S-EPMC5137966 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Publications
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease.
MacLeod Ruth R Hillert Ellin-Kristina EK Cameron Ryan T RT Baillie George S GS
Future science OA 20151101 3
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main pathological features of AD is the presence in the brain of senile plaques mainly composed of aggregated β amyloid (Aβ), a derivative of the longer amyloid precursor protein (APP). The amyloid hypothesis proposes that the accumulation of Aβ with ...[more]
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