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PCAN: phenotype consensus analysis to support disease-gene association.

ABSTRACT: Bridging genotype and phenotype is a fundamental biomedical challenge that underlies more effective target discovery and patient-tailored therapy. Approaches that can flexibly and intuitively, integrate known gene-phenotype associations in the context of molecular signaling networks are vital to effectively prioritize and biologically interpret genes underlying disease traits of interest.We describe Phenotype Consensus Analysis (PCAN); a method to assess the consensus semantic similarity of phenotypes in a candidate gene's signaling neighborhood. We demonstrate that significant phenotype consensus (p?

SUBMITTER: Godard P 

PROVIDER: S-EPMC5142268 | biostudies-other | 2016 Dec

REPOSITORIES: biostudies-other

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PCAN: phenotype consensus analysis to support disease-gene association.

Godard Patrice P   Page Matthew M  

BMC bioinformatics 20161207 1

<h4>Background</h4>Bridging genotype and phenotype is a fundamental biomedical challenge that underlies more effective target discovery and patient-tailored therapy. Approaches that can flexibly and intuitively, integrate known gene-phenotype associations in the context of molecular signaling networks are vital to effectively prioritize and biologically interpret genes underlying disease traits of interest.<h4>Results</h4>We describe Phenotype Consensus Analysis (PCAN); a method to assess the co  ...[more]