PCAN: phenotype consensus analysis to support disease-gene association.
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ABSTRACT:
SUBMITTER: Godard P
PROVIDER: S-EPMC5142268 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Publications
PCAN: phenotype consensus analysis to support disease-gene association.
Godard Patrice P Page Matthew M
BMC bioinformatics 20161207 1
<h4>Background</h4>Bridging genotype and phenotype is a fundamental biomedical challenge that underlies more effective target discovery and patient-tailored therapy. Approaches that can flexibly and intuitively, integrate known gene-phenotype associations in the context of molecular signaling networks are vital to effectively prioritize and biologically interpret genes underlying disease traits of interest.<h4>Results</h4>We describe Phenotype Consensus Analysis (PCAN); a method to assess the co ...[more]
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