Ontology highlight
ABSTRACT:
SUBMITTER: Medunjanin S
PROVIDER: S-EPMC5144080 | biostudies-other | 2016 Dec
REPOSITORIES: biostudies-other
Medunjanin Senad S Schleithoff Lisa L Fiegehenn Christian C Weinert Soenke S Zuschratter Werner W Braun-Dullaeus Ruediger C RC
Scientific reports 20161208
The NF-κB signaling pathway is central for the innate immune response and its deregulation is found in multiple disorders such as autoimmune, chronic inflammatory and metabolic diseases. IKKγ/NEMO is essential for NF-κB activation and NEMO dysfunction in humans has been linked to so-called progeria syndromes, which are characterized by advanced ageing due to age-dependent inflammatory diseases. It has been suggested that glycogen synthase kinase-3β (GSK-3β) participates in NF-κB regulation but t ...[more]